Police activity connected to the search for Nancy Guthrie, the missing mother of US news anchor Savannah Guthrie, is under way at a residence about two miles from her home.

Armed police teams have been seen coming in and going from the area, with a sheriff's vehicle blocking the road.

This follows the discovery of DNA at Guthrie's address that does not belong to her or anyone close to her.

The 84-year-old disappeared in the middle of the night from her home in Tucson, Arizona, nearly two weeks ago. Authorities believe she was taken against her will.

In a social media post, the sheriff's department indicated that law enforcement activity was ongoing in relation to the Guthrie case.

Pima County Sheriff Chris Nanos stated that investigators were actively working a lead", as more than a dozen law enforcement vehicles, including SWAT teams and forensic units, were seen in the area.

Several gloves were also found nearby, with one of the closest discovered around two miles from Nancy Guthrie's residence. The department clarified that reports of a glove being found inside her home are inaccurate.

All collected evidence has been sent for laboratory analysis.

On Thursday, the FBI released a physical description of a suspect identified from doorbell camera footage, revealing they are a male of average build. The FBI has also raised the reward for information on Guthrie’s whereabouts from $50,000 to $100,000.

The suspect was reported to be carrying a distinctive 25-litre Ozark Trail Hiker Pack backpack, and investigators are appealing for additional video footage from nearby residents.

Authorities have emphasized the urgency of the situation, noting that Nancy Guthrie has limited mobility and requires daily medication. Savannah Guthrie and her siblings have made emotional pleas on social media, expressing their belief that their mother is still alive and offering payment for her safe return.