Garr’s illustrious career began in the vibrant world of dance, thanks in part to her mother's influence. Starting as a background dancer in Elvis Presley films, she transitioned from dance to acting, securing her first significant role in the road company of West Side Story. 1974 marked a pivotal year for Garr with her breakthrough performance in The Conversation, leading to her iconic role alongside Gene Wilder in Young Frankenstein, which introduced her comedic flair to broader audiences.

Known for both her comedic and dramatic prowess, Garr's filmography expanded to include notable appearances in Close Encounters of the Third Kind and The Black Stallion, as well as television hits like Star Trek and That Girl. Despite various health challenges, including an aneurysm surgery in 2007, Garr remained a beloved figure, deeply respected for her contributions to film and her inspiring advocacy work.